| Region | Level | Instrument | Chair | Name | School |
| 5 | SR | Flute | 01 | Tiara Walton | Goose Creek High School |
| 5 | SR | Flute | 02 | Jaela Simms | Sumter High School |
| 5 | SR | Flute | 03 | Kayla Moses | S.C. Governor’s School for the Arts and Humanities – REGION 5 |
| 5 | SR | Flute | 04 | Jennifer Polfleit | Stratford High School |
| 5 | SR | Flute | 05 | Madison Liles | Cane Bay High School |
| 5 | SR | Flute | 06 | Madison Davis | Aynor High School |
| 5 | SR | Flute | 07 | Hannah Bridges | West Florence High School |
| 5 | SR | Flute | 08 | Jenny Le | Hanahan High School |
| 5 | SR | Flute | 09 | Mary McBane | Hanahan High School |
| 5 | SR | Flute | 10 | Ashley Leal-Diaz | Conway High School |
| 5 | SR | Flute | 11 | Grace Wallace | Cane Bay High School |
| 5 | SR | Flute | 12 | Sydney Ballard | Hanahan High School |
| 5 | SR | Flute | A01 | Lilly Ellis | Goose Creek High School |
| 5 | SR | Flute | A02 | Kaylee Jackson | McBee High School |
| 5 | SR | Flute | A03 | Elaine Lizarondo | Cane Bay High School |
| 5 | SR | Flute | A04 | Lamika Cousar | Dillon High School |
| 5 | SR | Flute | A05 | Vanessa Venegas | Carolina Forest High School |
| 5 | SR | Flute | A06 | Rachel Wyatt | Stratford High School |
| 5 | SR | Oboe | 01 | Ashlynn Andrews | Hanahan High School |
| 5 | SR | Oboe | 02 | Nicole Tran | Cane Bay High School |
| 5 | SR | Oboe | 03 | Kezia Dentley | Dillon High School |
| 5 | SR | Oboe | 04 | Michela Urso | Carolina Forest High School |
| 5 | SR | Bassoon | 01 | Katherine Jordan | Hartsville High School |
| 5 | SR | Bassoon | 02 | Andrew Gossett | Hanahan High School |
| 5 | SR | Bassoon | 03 | Jackson Stone | Dillon High School |
| 5 | SR | Clarinet | 01 | Teague McCracken | Stratford High School |
| 5 | SR | Clarinet | 02 | Noah Ledbetter | Stratford High School |
| 5 | SR | Clarinet | 03 | Jaydon Wright | West Florence High School |
| 5 | SR | Clarinet | 04 | Hanah Kerrigan | Cane Bay High School |
| 5 | SR | Clarinet | 05 | Sam Holberg | West Florence High School |
| 5 | SR | Clarinet | 06 | Cheyenne Hoover | Goose Creek High School |
| 5 | SR | Clarinet | 07 | Alex Libby | Sumter High School |
| 5 | SR | Clarinet | 08 | Collin Creach | Hartsville High School |
| 5 | SR | Clarinet | 09 | Ashia Grant | Hanahan High School |
| 5 | SR | Clarinet | 10 | Nia Misuraca | Hanahan High School |
| 5 | SR | Clarinet | 11 | Zary Gouin | Waccamaw High School |
| 5 | SR | Clarinet | 12 | Antania McCollum | Dillon High School |
| 5 | SR | Clarinet | 13 | Savannah Holley | Goose Creek High School |
| 5 | SR | Clarinet | 14 | Maya Youssef | Hanahan High School |
| 5 | SR | Clarinet | 15 | Marinique Rolle | Goose Creek High School |
| 5 | SR | Clarinet | 16 | Kiara Edge | Dillon High School |
| 5 | SR | Clarinet | 17 | Victor Sanchez | Conway High School |
| 5 | SR | Clarinet | 18 | Yesenia Martinez | North Myrtle Beach High School |
| 5 | SR | Clarinet | 19 | CJ Mungin | Stratford High School |
| 5 | SR | Clarinet | 20 | Imani Stuckey | Darlington High School |
| 5 | SR | Clarinet | 21 | Shobria Sowells | Dillon High School |
| 5 | SR | Clarinet | 22 | Stephanie Buero | Berkeley High School |
| 5 | SR | Clarinet | 23 | Patricia Smith | Socastee High School |
| 5 | SR | Clarinet | 24 | Dasia Council | Carolina Forest High School |
| 5 | SR | Clarinet | A01 | Nastajia Hamilton | Manning High School |
| 5 | SR | Clarinet | A02 | Sabria Washington | Sumter High School |
| 5 | SR | Clarinet | A03 | Sidney Clark | Hanahan High School |
| 5 | SR | Clarinet | A04 | Brianna Johnson | Georgetown High School |
| 5 | SR | Clarinet | A05 | Kierra Robertson | Sumter High School |
| 5 | SR | Clarinet | A06 | Tamara-Lee Morris | Cane Bay High School |
| 5 | SR | Clarinet | A07 | Alicia Lucas | Socastee High School |
| 5 | SR | Clarinet | A08 | T’Asia Smalls | Loris High School |
| 5 | SR | Bass Clarinet | 01 | Christopher Melendez | Socastee High School |
| 5 | SR | Bass Clarinet | 02 | Ashleigh Hamilton | Goose Creek High School |
| 5 | SR | Bass Clarinet | 03 | Daney Brickles | Berkeley High School |
| 5 | SR | Bass Clarinet | 04 | Allyssa Weir | Stratford High School |
| 5 | SR | Bass Clarinet | A01 | Matthew James | Sumter High School |
| 5 | SR | Bass Clarinet | A02 | Keevon Fullard | Sumter High School |
| 5 | SR | Contra Clarinet | 01 | Zharia Roberts | Cane Bay High School |
| 5 | SR | Contra Clarinet | 02 | Rylee Toth | Sumter High School |
| 5 | SR | Contra Clarinet | A01 | La-Taurean Brigman | Dillon High School |
| 5 | SR | Alto Sax | 01 | Sessaly Mitchell-Nelson | Sumter High School |
| 5 | SR | Alto Sax | 02 | Carlton Williams | Cane Bay High School |
| 5 | SR | Alto Sax | 03 | Maclain Freeman | Hanahan High School |
| 5 | SR | Alto Sax | 04 | Leslie Orellana | Sumter High School |
| 5 | SR | Alto Sax | 05 | Trey Binnom | Hanahan High School |
| 5 | SR | Alto Sax | 06 | Jasmine Brunson | Sumter High School |
| 5 | SR | Alto Sax | A01 | Sarah Dumont | Stratford High School |
| 5 | SR | Alto Sax | A02 | Samuel Hickman | Conway High School |
| 5 | SR | Alto Sax | A03 | Jamont McRae | Dillon High School |
| 5 | SR | Tenor Sax | 01 | Landon Bailey | Sumter High School |
| 5 | SR | Tenor Sax | 02 | Madison Quick | Central High School |
| 5 | SR | Tenor Sax | A01 | Abigail Galunas | Goose Creek High School |
| 5 | SR | Bari Sax | 01 | Patrick Johnson | Wilson High School |
| 5 | SR | Bari Sax | A01 | Zachary Odom | Socastee High School |
| 5 | SR | Trumpet | 01 | Dakota Nealey | Carolina Forest High School |
| 5 | SR | Trumpet | 02 | Hannah Miller | Waccamaw High School |
| 5 | SR | Trumpet | 03 | Cameron McDuffie | Sumter High School |
| 5 | SR | Trumpet | 04 | Greg Belisle | Cane Bay High School |
| 5 | SR | Trumpet | 05 | Carlos Santamarina | Carolina Forest High School |
| 5 | SR | Trumpet | 06 | Alec Daniels | Latta High School |
| 5 | SR | Trumpet | 07 | Matthew Price | West Florence High School |
| 5 | SR | Trumpet | 08 | Ben Green | Wilson High School |
| 5 | SR | Trumpet | 09 | Camryn Finley | Socastee High School |
| 5 | SR | Trumpet | 10 | Miles Hutcherson | Socastee High School |
| 5 | SR | Trumpet | 11 | Storm Milan | Socastee High School |
| 5 | SR | Trumpet | 12 | Julia Gifford | Socastee High School |
| 5 | SR | Trumpet | 13 | Michael Walton | Carolina Forest High School |
| 5 | SR | Trumpet | 14 | Jeylen Kirkland | Darlington High School |
| 5 | SR | Trumpet | 15 | Jack DeRiso | Saint James High School |
| 5 | SR | Trumpet | 16 | Mauricio Melara | Goose Creek High School |
| 5 | SR | Trumpet | A01 | Rodrigo Delgado | Goose Creek High School |
| 5 | SR | Trumpet | A02 | Allison Brown | Cheraw High School |
| 5 | SR | Trumpet | A03 | Jacobo Artistizabal | Carolina Forest High School |
| 5 | SR | Trumpet | A04 | Ashanti Milling | Darlington High School |
| 5 | SR | Trumpet | A05 | Michael Miller | Manning High School |
| 5 | SR | Trumpet | A06 | Joshua Harris | Lakewood High School |
| 5 | SR | Trumpet | A07 | Janiqua McFarland | Darlington High School |
| 5 | SR | Horn | 01 | Isabella Hirsch | Carolina Forest High School |
| 5 | SR | Horn | 02 | DeAndre Lloyd | Goose Creek High School |
| 5 | SR | Horn | 03 | Haley Bullock | Goose Creek High School |
| 5 | SR | Horn | 04 | Nicholas Howard | Sumter High School |
| 5 | SR | Horn | 05 | Jazmine Hazeres | Goose Creek High School |
| 5 | SR | Horn | 06 | Mercedes Cantrell | Stratford High School |
| 5 | SR | Horn | 07 | Evie O’Saben | Stratford High School |
| 5 | SR | Horn | 08 | Carson Mack | Central High School |
| 5 | SR | Horn | A01 | Colby Gerald | Loris High School |
| 5 | SR | Horn | A02 | Laney Midgley | Cheraw High School |
| 5 | SR | Horn | A03 | Katelyn Ruth | Waccamaw High School |
| 5 | SR | Horn | A04 | Collier Garrison | McBee High School |
| 5 | SR | Trombone | 01 | Elsie Brumett | Chesterfield High School |
| 5 | SR | Trombone | 02 | Olivia Walker | Stratford High School |
| 5 | SR | Trombone | 03 | Dorien Steed | Hanahan High School |
| 5 | SR | Trombone | 04 | Te’Ondrus Billie | Sumter High School |
| 5 | SR | Trombone | 05 | Raleigh McMillian | Socastee High School |
| 5 | SR | Trombone | 06 | Ev Seay | Latta High School |
| 5 | SR | Trombone | 07 | Joseph Mack | Manning High School |
| 5 | SR | Trombone | 08 | Tatyana Sanders | Dillon High School |
| 5 | SR | Trombone | 09 | Anthony Williams | Cane Bay High School |
| 5 | SR | Trombone | A01 | Ethan Strickland | Wilson High School |
| 5 | SR | Trombone | A02 | Xavier Wright | Wilson High School |
| 5 | SR | Trombone | A03 | Brandon Bethea | Dillon High School |
| 5 | SR | Trombone | A04 | Ayana Russell | Goose Creek High School |
| 5 | SR | Trombone | A05 | Daniel Sturgill | Hartsville High School |
| 5 | SR | Euphonium | 01 | Joshua Turner | Carolina Forest High School |
| 5 | SR | Euphonium | 02 | Matthew Shranko | West Florence High School |
| 5 | SR | Euphonium | 03 | Deasia McLellan | Dillon High School |
| 5 | SR | Euphonium | 04 | Deonte Boston | Wilson High School |
| 5 | SR | Euphonium | A01 | Qua’Dragus Nelson | Dillon High School |
| 5 | SR | Euphonium | A02 | Nathan Dildine | Hanahan High School |
| 5 | SR | Tuba | 01 | Quandarius “Tray” Kelly | Chesterfield High School |
| 5 | SR | Tuba | 02 | Scout Stewart | Socastee High School |
| 5 | SR | Tuba | 03 | Daniel Howard | Sumter High School |
| 5 | SR | Tuba | 04 | Briana Mouzon | S.C. Governor’s School for the Arts and Humanities – REGION 5 |
| 5 | SR | Tuba | 05 | Jonathan Amado | Cane Bay High School |
| 5 | SR | Tuba | 06 | Anthony Degrazio | Lakewood High School |
| 5 | SR | Tuba | 07 | Derek Taylor | Goose Creek High School |
| 5 | SR | Tuba | 08 | Rebecca Whisnant | Loris High School |
| 5 | SR | Tuba | A01 | Bryanna Jackson | Timberland High School |
| 5 | SR | Tuba | A02 | Nicholas Joyner | Darlington High School |
| 5 | SR | Tuba | A03 | Ja-Marius Bethea | Dillon High School |
| 5 | SR | Tuba | A04 | Christian Legrand-Wilson | Wilson High School |
| 5 | SR | Bass Trombone | 01 | Marshall Bryan | North Myrtle Beach High School |
| 5 | SR | Bass Trombone | A01 | Bryce Eubanks | McBee High School |
| 5 | SR | Percussion | 01 | Hannah Sturdivant | Cane Bay High School |
| 5 | SR | Percussion | 02 | Alicia Santarelli | Hanahan High School |
| 5 | SR | Percussion | 03 | Aidan Gowe | Hanahan High School |
| 5 | SR | Percussion | 04 | Nathan Costas | Sumter High School |
| 5 | SR | Percussion | 05 | Marcus X | Cane Bay High School |
| 5 | SR | Percussion | 06 | Melanie Tieman | Stratford High School |
| 5 | SR | Percussion | 07 | T’Niya Williams | Dillon High School |
| 5 | SR | Percussion | A01 | Jackson Knight | Hanahan High School |
| 5 | SR | Percussion | A02 | Jalen Tingin | Goose Creek High School |
| 5 | SR | Percussion | A03 | Shaun Brown | North Myrtle Beach High School |
| 5 | SR | Percussion | A04 | Bruce Nelson | Dillon High School |
| 5 | SR | Timpani | 01 | Betty Rugema | Goose Creek High School |
| 5 | SR | Timpani | A01 | Jarred Daniel | Goose Creek High School |